Study Overview
This study looked at how effective and safe a 0.025% tretinoin cream is for treating dark skin patches (hyperpigmentation) in the armpits caused by a skin condition called acanthosis nigricans (AN).
Key Findings
- Acanthosis nigricans causes darkening and thickening of the skin, especially in body folds like the armpits.
- This research tested 0.025% tretinoin cream against a control cream over 12 weeks.
- Participants applied tretinoin on one armpit and the control cream on the other.
- After 8 weeks of treatment, results were measured using the melanin index, which tracks skin pigmentation.
- The study involved 20 participants, with significant results showing tretinoin reduced hyperpigmentation much more than the control (p < 0.001).
- By the end of the study, 75% of those using tretinoin reported over 75% improvement, while only 35% using the control cream saw similar results.
- Some mild side effects were noted, such as slight redness, peeling, and itching.
Practical Solutions and Value
The findings suggest that 0.025% tretinoin cream is a safe and effective treatment for axillary hyperpigmentation linked to AN, with minimal side effects.
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