A Study on Toripalimab for Advanced Cervical Cancer
Objective
The goal of this study was to evaluate how effective and safe toripalimab is when used with platinum-based chemoradiotherapy for treating locally advanced cervical cancer.
Methods
We included 82 patients diagnosed with locally advanced cervical cancer at Tianjin Medical University Cancer Institute and Hospital from May 2019 to August 2022. After receiving concurrent chemoradiotherapy, patients underwent six cycles of treatment with toripalimab, paclitaxel, and platinum-based agents. We measured:
- Primary Endpoint: Objective Response Rate (ORR)
- Secondary Endpoints: Disease Control Rate (DCR), safety, progression-free survival (PFS), and overall survival (OS).
Results
The average age of patients was 53.6 years, with 92.7% having squamous cell carcinoma. Key findings include:
- ORR and DCR: 87.8% (72 patients)
- Complete Remission: 78.0% (64 patients)
- Partial Remission: 9.8% (8 patients)
- Disease Progression: 9.8% (8 patients)
- Adverse Events: 45.1% experienced treatment-related side effects, with 20.7% having severe reactions.
The most common severe side effect was radiation enteritis (6.1%). The median follow-up time was 20.6 months, with promising survival rates observed.
Conclusion
Patients with locally advanced cervical cancer showed favorable response rates when treated with toripalimab alongside platinum-based chemoradiotherapy and consolidation chemotherapy.
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