A Randomized Controlled Trial to Determine the Impact of Resistance Training versus Aerobic Training on the Management of FGF-21 and Related Physiological Variables in Obese Men with Type 2 Diabetes Mellitus

A Randomized Controlled Trial to Determine the Impact of Resistance Training versus Aerobic Training on the Management of FGF-21 and Related Physiological Variables in Obese Men with Type 2 Diabetes Mellitus

Key Findings:

Fibroblast growth factor 21 (FGF-21) is a potential therapeutic target for insulin resistance in type 2 diabetes. This study compared the effects of 12-week resistance training (RT) and aerobic training (AT) on FGF-21 levels and metabolic symptoms in obese men with type 2 diabetes.

Both RT and AT significantly improved FGF-21 levels, glucose metabolism, lipid profile, hormonal changes, strength, and aerobic capacity. RT showed greater improvements in fasting blood sugar, insulin resistance, testosterone, cortisol, FGF-21, and maximal strength, while AT was more effective in improving cholesterol, triglycerides, HDL, LDL, and aerobic capacity.

Practical Implications:

RT is effective for controlling FGF-21 levels and glucose balance, as well as inducing hormonal changes, while AT is more suitable for improving lipid profiles in overweight men with type 2 diabetes mellitus.

Value:

This study provides practical insights into the benefits of RT and AT for managing FGF-21 levels and related physiological variables in obese men with type 2 diabetes, offering valuable guidance for personalized exercise interventions in clinical practice.

PMID:

39228768

PMC:

PMC11366843

DOI:

10.52082/jssm.2024.495

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