Can Citicoline and Vitamin B12 Help Heal Corneal Nerves After Cross-Linking?
Study Overview
This study looked at how topical citicoline, vitamin B12, and hyaluronic acid (OMK2 eye drops) affect the healing of corneal nerves after corneal cross-linking (CXL) in patients with keratoconus (KC).
Study Details
A total of 44 eyes from 22 patients with KC who underwent CXL were included. One eye received OMK2 eye drops along with standard treatment (OMK2 group), while the other eye received only standard treatment (control group). The study measured:
- Corneal sensitivity
- Tear film stability
- Central corneal thickness (CCT)
- Corneal sub-basal nerve plexus (sbNP) parameters
Key Findings
After CXL, the results showed:
- In the control group, corneal nerve fiber area (CNFA) decreased significantly (p < 0.001).
- In the OMK2 group, CNFA remained stable (p = 0.283).
- Other nerve parameters decreased in both groups (all p < 0.05).
- CCT in the OMK2 group did not change significantly (p = 0.052), while it decreased in the control group (p = 0.009).
- No significant differences in corneal sensitivity or tear film stability between the groups (all p > 0.05).
Conclusion
Using OMK2 eye drops after CXL may help maintain a stable CNFA and promote faster recovery of CCT.
Importance of Clinical Trials
Clinical trials are essential for developing safe and effective treatments. They help translate research findings into everyday medical practice.
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