Itinai.com close up of doctor hands doing procedure for patie b62daafd ae78 4416 b629 6e501ccde339 2
Itinai.com close up of doctor hands doing procedure for patie b62daafd ae78 4416 b629 6e501ccde339 2

Clinical and cost-effectiveness of pessary self-management versus clinic-based care for pelvic organ prolapse in women: the TOPSY RCT with process evaluation

Clinical Trial Results: Pessary Self-Management vs. Clinic-Based Care for Pelvic Organ Prolapse

Key Findings

  • Self-management was acceptable and cost-effective, leading to fewer complications
  • Quality of life for women with prolapse did not significantly improve or worsen compared with clinic-based care
  • Situational factors impacted adherence and effectiveness in both groups

Practical Solutions and Value

  • The self-management intervention involved a 30-minute teaching appointment, an information leaflet, a 2-week follow-up telephone call, and a local clinic telephone helpline number
  • Cost-effective at a willingness-to-pay threshold of £20,000 per quality-adjusted life-year gained
  • Our AI-driven platform consolidates ICD-11 standards, clinical protocols, and research into a single, easily accessible knowledge base for clinicians
  • Mobile apps support scheduling, monitoring treatments, and telemedicine, making it easier to manage patient care and expand services digitally

Study Information

  • Study Registration: This study is registered as ISRCTN62510577
  • Funding: Funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 16/82/01)

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