Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial

Summary of Clinical Trial Findings

Study Focus

This study investigated how well oral supplements of magnesium and vitamin D can reduce mild to moderate depression symptoms in people suffering from long-COVID.

Key Outcomes

  • Participants: 60 individuals aged around 53 years with low magnesium and vitamin D levels, along with mild to moderate depression.
  • Method: Participants were divided into two groups: one group received magnesium (1300 mg) and vitamin D (4000 IU), while the other group received only vitamin D for four months.
  • Results:
    • Significant improvement in depression symptoms was noted in those taking both supplements, with scores improving from an average of 28.8 to 9.2.
    • 73.2% of the intervention group showed a marked reduction in depressive symptoms, reaching scores considered normal, compared to 34.5% in the control group.
  • Safety: Mild side effects were noted but did not require stopping the treatment.

Practical Solutions and Value

This trial highlights that combining magnesium and vitamin D can effectively improve mental health in individuals with long-COVID. This information can guide healthcare providers in recommending these supplements for symptomatic relief.

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