Comparative study between efficacy of Excimer light with topical Tacrolimus 0.1% versus excimer light with topical Bimatoprost 0.01% in treatment of facial Vitiligo

Comparative Study on Treatment of Facial Vitiligo

Published in Arch Dermatol Res. 2024 Jun 8;316(7):350

Loss and absence of melanocytes due to various factors lead to vitiligo, the most common pigmentation disorder. This study aimed to compare the effectiveness and safety of two treatments for facial vitiligo: excimer light with topical tacrolimus ointment 0.1% and excimer light with topical bimatoprost gel 0.01%.

48 patients with facial vitiligo participated in the study, with 24 patients in each treatment group. Clinical improvement based on the quartile grading scale at the end of treatment did not show any statistically significant difference between the two groups. The majority of subjects in both groups experienced good to excellent improvement. Only 20.9% of patients in the tacrolimus group and 33.3% in the bimatoprost group achieved less than 50% repigmentation (p = 0.889). The study demonstrated that 0.01% topical bimatoprost gel in combination with excimer light is considered safe and effective as a treatment for nonsegmental facial vitiligo with comparable results to 0.1% tacrolimus.

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