Echocardiographic Phenotypes of Diabetic Myocardial Disorder

Overview

Diabetic myocardial disorder (DbMD) is a significant condition linked to heart failure. It is measured through echocardiograms or cardiac biomarkers. This study looks at how DbMD evolves over 15 months in patients with heart failure at an early stage.

Study Objective

The goal was to examine the changes in four different DbMD groups, categorizing based on biomarkers, heart function, or both.

Methodology

The ARISE-HF trial focused on patients with well-controlled type 2 diabetes. A total of 1,858 participants (average age 67; half women) were screened for heart issues. Out of them, 669 had DbMD, and their exercise capacity was tested at the start and again after 15 months.

Key Findings

Out of 1,463 participants with DbMD, the classification showed:

49% had only elevated cardiac biomarkers
16% had systolic dysfunction or heart enlargement
9% had diastolic dysfunction
5% had overlapping issues

46% of patients showed reduced exercise capacity
Similar declines in exercise capability were noted across all groups over 15 months

Conclusion

Patients with multiple heart function issues experienced the most significant exercise capacity reductions. However, all groups had similar changes in exercise tolerance during the follow-up period.

Clinical Trial Registration

ARISE-HF, NCT04083339

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