Effect of weight-maintaining ketogenic diet on glycemic control and insulin sensitivity in obese T2D subjects

Effect of Weight-Maintaining Ketogenic Diet on Diabetes Management

Study Overview

A recent study published in BMJ Open Diabetes Research & Care explored the impact of low carbohydrate ketogenic diets on people with obesity and type 2 diabetes (T2D). These diets aim to help with weight loss, better blood sugar control, and lower insulin resistance.

Research Details

The study involved 29 overweight participants who followed one of three diets for 10 days:

  • Standard diet to maintain weight
  • Ketogenic diet to maintain weight
  • Ketogenic diet with ketone ester supplement (8 g every 8 hours)

All participants underwent tests to measure their glucose tolerance and insulin sensitivity at the beginning of the study.

Key Findings

  • Body weight and fat percentage remained stable in all groups.
  • Plasma levels of beta-hydroxybutyrate (a ketone) doubled, indicating changes in how the body processes energy.
  • Glucose tolerance showed minor changes, but overall insulin sensitivity and metabolic health did not improve in any group.

Conclusion

Without weight loss, a low carbohydrate ketogenic diet does not improve blood sugar control, insulin sensitivity, or other metabolic factors.

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