Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial

Efficacy of Esketamine for Prenatal Depression in Mothers

Key Results and Practical Considerations

Results: A single low dose of esketamine significantly reduced the prevalence of major depressive episodes at 42 days postpartum in mothers with prenatal depression when compared to a placebo. This represents a substantial reduction in postpartum depression risk. Additionally, esketamine led to lower depression scores on standardized tests at seven and 42 days postpartum.

Adverse Events: The esketamine group experienced a higher incidence of neuropsychiatric adverse events, but these symptoms were short-lived and did not require drug intervention.

Value: The study highlights the potential practical value of esketamine in reducing postpartum depression in mothers with prenatal depression, with manageable transient side effects.

Future Application: This research offers potential insights for enhancing patient outcomes in clinical practice.

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