Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for Demodex Blepharitis

Purpose

This study aimed to test how well a treatment using terpinen-4-ol (T4O) and eyelid deep cleaning works for Demodex blepharitis.

Methods

We conducted a trial with 40 patients diagnosed with Demodex blepharitis at the Cornea Specialty Clinic of Hankou Aier Eye Hospital. Participants were divided into two groups: one used T4O cleaning wipes alone for two months, while the other used T4O wipes and received deep eyelid cleaning during three visits. We followed up one month after treatment to assess the results.

Results

After two months, both groups saw a significant drop in Demodex mite counts. However, the T4O group experienced an increase in mites after treatment ended. In contrast, the combination group maintained lower mite counts even after treatment, showing better results at the three-month follow-up. Both groups had improvements in symptoms, but only the combination group showed significant progress in the following months. No side effects were reported.

Conclusions

Using T4O wipes alone reduces Demodex mites, but there is a risk of them returning after stopping treatment. Combining T4O with eyelid deep cleaning is more effective for reducing mite counts and improving symptoms.

Practical Solutions and Value

This study highlights the importance of combining treatments for better outcomes in managing Demodex blepharitis. It shows that a longer treatment duration and additional therapies can lead to sustained improvements.

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