Exploring Therapeutic Mechanisms of Chuan Huang Fang-II in the Treatment of Acute Kidney Injury on Chronic Kidney Disease Patients
Study Information
Journal: Ren Fail. 2024 Dec;46(1):2356021
DOI: 10.1080/0886022X.2024.2356021
Date: Epub 2024 May 24
Objective
This study evaluates the effectiveness and safety of CHF-II combined with RG for treating AKI on CKD (A on C) and investigates potential therapeutic mechanisms through lipidomics analysis.
Methods
98 patients were randomly assigned to the RG or RG + CHF groups. Both groups received RG therapy, with the RG + CHF group also receiving CHF-II treatment for two weeks. Evaluation endpoints included changes in renal function, blood lipid profiles, urinary AKI biomarkers, and TCM symptoms before and after treatment. Serum samples were collected for lipid metabolite analysis.
Results
The clinical effective rate in the RG + CHF group was 73.5%, compared to 40.8% in the RG group. TCM syndrome scores in the RG + CHF group showed a more pronounced decrease. Both groups showed improvements in renal function and lipid profiles, with greater improvements observed in the RG + CHF group. Urinary AKI biomarkers decreased more in the RG + CHF group. No serious adverse events occurred during the trial. 58 different lipid metabolites and 48 lipid biomarkers were identified, suggesting possible metabolic pathways involved in the therapeutic action of CHF-II.
Conclusion
CHF-II effectively alleviated kidney injury and improved TCM syndrome scores in patients with A on C. Lipid differential metabolites could serve as diagnostic indicators for AKI in patients with CKD. The possible metabolic pathways might be implicated in the therapeutic action of CHF-II in the prevention and treatment of patients with A on C.
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