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Impact of Lemborexant on Daytime Sleepiness in Patients with Insomnia and Mild Sleep Apnea
Objective
This study aimed to see how lemborexant, a medication for insomnia, affects morning alertness in adults with both insomnia and mild obstructive sleep apnea (COMISA).
Background
COMISA can lead to daytime sleepiness and cognitive problems. Some sleep medications can make morning sleepiness worse, so it’s crucial to find out if lemborexant helps improve alertness after a full night’s sleep.
Study Design
Out of 1006 participants, 410 were over 55 years old, had insomnia, and mild sleep apnea. They were given either a placebo, lemborexant 5 mg (LEM5), lemborexant 10 mg (LEM10), or another sleep medication called zolpidem in a month-long study. Participants rated their morning alertness daily on a scale from 1 (very sleepy) to 9 (very alert).
Results
Before treatment, 22.7% of participants on placebo, 32.1% on LEM5, and 26.9% on LEM10 reported feeling sleepy. After treatment, a higher percentage of those taking lemborexant felt more alert in the mornings compared to those on placebo.
Conclusions
Although the study was small, it showed that lemborexant may help improve morning alertness in patients with COMISA compared to a placebo. This suggests that lemborexant could be a good option for managing insomnia in these patients.
Measurable Outcomes
We can set clear goals to assess how lemborexant impacts daytime alertness in clinics and for patients.
Selecting AI Tools
Identify artificial intelligence tools that can support the clinical needs related to the impact of lemborexant on sleepiness and alertness.
Implementation Steps
Start with a pilot project using AI solutions to track the real-world impact of lemborexant on morning alertness.
Contact Us
For more information on AI solutions in medical management, reach out to us:
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