GLORIA Trial: Combining CXCL12 Inhibition and Radiotherapy in Glioblastoma
Key Findings:
The GLORIA trial combined radiotherapy with the CXCL12-neutralizing aptamer olaptesed pegol (NOX-A12) in patients with newly-diagnosed glioblastoma. The study found that the treatment was safe and well-tolerated, with no dose-limiting toxicities or treatment-related deaths.
Increasing the NOX-A12 dose levels led to higher NOX-A12 plasma levels, and a significant proportion of patients showed radiographic responses, with some reaching partial remission.
The median progression-free survival (PFS) was 174 days, and the median overall survival (OS) was 389 days. Notably, higher frequency of CXCL12+ endothelial and glioma cells was associated with longer PFS under NOX-A12 treatment.
Practical Solutions and Value:
Clinical trials like GLORIA are essential for developing safe and effective treatments. The findings from this trial provide valuable insights into the potential of combining CXCL12 inhibition and radiotherapy in glioblastoma treatment.
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