Oral Lactoferrin for Treating Anemia in Children with Chronic Kidney Disease
Study Overview
Anemia in children often arises from chronic kidney disease (CKD), negatively impacting their health and well-being. Traditional treatments, like injectable iron, come with several side effects.
Trial Details
This clinical trial aimed to compare the effectiveness of oral lactoferrin versus intravenous (IV) iron dextran in treating CKD-related anemia in children. The study involved 60 children diagnosed with this condition, divided into two groups:
- Group 1: 30 children received 100 mg of oral lactoferrin daily for 3 months.
- Group 2: 30 children received 50 mg of IV iron dextran three times a week for 3 months.
Results
Both treatments effectively managed anemia. However, oral lactoferrin showed better results in improving various blood parameters, including:
- Hemoglobin (Hb)
- Red Blood Cells (RBCs)
- Mean Corpuscular Hemoglobin (MCH)
- Iron levels
- Red Cell Distribution Width (RDW-SD)
- Mean Corpuscular Hemoglobin Concentration (MCHC)
- Inflammatory markers (IL-6, GDF-15)
Although IV iron dextran also showed improvements, particularly in iron levels and some other blood markers, there was no significant difference between both treatments after 3 months.
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