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Itinai.com close up of doctor hands doing procedure for patie b62daafd ae78 4416 b629 6e501ccde339 1

Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial

Pentoxifylline Reduces Subclinical Atherosclerosis in Patients with Type 2 Diabetes and Chronic Kidney Disease

Key Findings:

Pentoxifylline (PTF) shows positive effects on the progression of subclinical atherosclerosis (SA) in patients with type 2 diabetes mellitus and chronic kidney disease (CKD).

Practical Solutions:

PTF treatment resulted in improved carotid intima-media thickness (CIMT), increased levels of the cardiovascular health protein Klotho (KL) in blood cells, and reduced inflammation.

Value:

PTF treatment, along with variations in KL expression and changes in HDL, were significant determinants for CIMT progression, independently of traditional risk factors. PTF demonstrates potential as a protective factor against the worsening of CIMT.

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