Study of Two Sedative Protocols for Drug-Induced Sleep Endoscopy
Practical Solutions and Value
Obstructive sleep apnea (OSA) is a common condition with serious health impacts. While CPAP is the standard treatment, some patients cannot tolerate it. Drug-induced sleep endoscopy (DISE) helps evaluate airway obstruction and plan surgical treatment. Our study compared two sedation protocols for DISE to improve its effectiveness.
Materials and Methods
We conducted the study in Bucharest, enrolling 31 patients who were randomly assigned to receive either propofol alone or a combination of remifentanil and propofol. Sedation was administered using target-controlled infusion, and we collected data on sedation levels, respiratory and cardiovascular parameters, and procedural incidents during DISE.
Results
Adding remifentanil to propofol significantly lowered the required propofol dose and shortened the time to achieve adequate sedation without increasing the risk of adverse events.
Conclusions
Adding remifentanil to propofol in DISE can improve safety and efficiency, providing a promising option for patients undergoing this procedure.
Value of Clinical Trials
Clinical trials are essential for developing safe and effective treatments. Our study aims to extend these benefits into medical practice, offering practical solutions for improving patient care.
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