Intermittent Theta-Burst Stimulation with D-Cycloserine: A New Hope for Suicidal Ideation Background Depressive disorders are common among people who die by suicide. Intermittent theta-burst stimulation (iTBS) is a noninvasive treatment for those struggling with hard-to-treat depression and at risk for suicide. Combining iTBS with D-cycloserine, a medication that enhances antidepressant effects, may offer better outcomes.…
Upadacitinib for Active Non-Radiographic Axial Spondyloarthritis: 2-Year Study Results Study Overview The SELECT-AXIS 2 study showed that upadacitinib significantly improved symptoms of active non-radiographic axial spondyloarthritis (nr-axSpA) over 52 weeks compared to a placebo. This report evaluates its effectiveness and safety over 2 years. Study Details Eligible adult patients with nr-axSpA were enrolled based on…
Youth Experiencing Homelessness at Risk for Suicide Study Overview This study looks at young adults who are homeless and at risk of suicide. It aims to understand their mental health challenges and how they use available services to help prevent suicide. Key Findings Out of 193 young adults studied, 126 (65.3%) were at low risk,…
Phase II Trial Overview Study Title: PADDLE This trial investigates the combination of nab-paclitaxel, ramucirumab, and nivolumab for patients with advanced gastric cancer (AGC) who have not responded to previous treatments. Background Patients with AGC often have limited survival after initial treatments. New research suggests that continuing immunotherapy after disease progression can be beneficial. The…
Tissue Doppler Echocardiography and Long-Term Cardiovascular Mortality Study Overview This study examines how tissue Doppler echocardiography can predict long-term cardiovascular mortality in hypertensive patients based on data from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Key Findings Background: Left ventricular diastolic function, evaluated through tissue Doppler echocardiography, has shown to predict cardiovascular events within 4 years…
Effect of Selective Caries Removal and Photobiomodulation on Postoperative Sensitivity Study Overview This clinical trial studied how selective removal of decay in deep cavities affects sensitivity after dental procedures. It involved 33 molars and compared three different treatment methods. Methods The teeth were divided into three groups: Control Group: Selective removal of infected dentine only.…
Intracameral Enoxaparin for Descemet Membrane Endothelial Keratoplasty: A Pilot Safety Study Study Overview The goal of this study was to assess the safety and results of using intracameral enoxaparin during Descemet membrane endothelial keratoplasty (DMEK). Methods The study included two parts: a clinical multicenter retrospective cohort arm (CA) and an ex vivo basic science arm…
Prediction and Prevention of Fascial Dehiscence After Laparotomy Objective The goal of this study was to assess how effective a special suture technique is in preventing fascial dehiscence (a complication where the surgical wound reopens) in patients who have certain risk factors during and after abdominal surgery. Methods This study looked at 112 patients who…
Phenomapping Patient Responses to CABG in Ischemic Cardiomyopathy Study Overview Coronary artery bypass grafting (CABG) can improve long-term survival for patients with heart failure and blocked arteries. This study explores how different patient characteristics affect the benefits of CABG. Research Methods We analyzed data from the STICHES trial, which compared CABG plus medical treatment to…
Study on Visceral Adipose Tissue and Weight Loss Background Visceral adipose tissue (VAT) is a harmful type of body fat that can negatively affect health, while superficial subcutaneous adipose tissue (SAT) has little to no negative impact. This study looks at how VAT area and its proportion of total abdominal fat during weight loss can…
Implementation of a Rapid Diagnostic Test for Infections Study Overview This study evaluated a new blood test, MeMed BV® (MMBV), which can tell if an infection is bacterial or viral. The test was used in ten urgent care centers (UCCs) from April 2022 to March 2023. The main goal was to see how the test…
Visual, Clinical, and Quality of Life Outcomes of a New Multifocal IOL Study Overview This study focuses on the BIOS Trifocal intraocular lens (IOL), designed to help patients see clearly at various distances without needing glasses. The lens aims to minimize issues like halos and glare, which can occur with other multifocal lenses. Key Features…
Shift from Chronic to Episodic Migraine Frequency in a Long-Term Phase 3 Study of Galcanezumab Background Chronic migraine (CM) is a severe condition where patients experience 15 or more headache days per month, with at least 8 being migraine-type headaches. Galcanezumab is a medication designed to prevent migraines. A key goal in treating CM is…
Effectiveness of Online Cognitive Behavioral Therapy for Mild Depression, Insomnia, and Panic: A Clinical Trial Study Background Many people experience symptoms of depression, insomnia, or panic that are not severe enough to be diagnosed as a mental health disorder. However, these symptoms can still make daily life challenging and lower quality of life. There is…
Unified Protocol vs Mentalization-Based Therapy for Adolescents With Borderline Personality Disorder Study Overview This study compares two treatments for adolescents with borderline personality disorder (BPD): Mentalization-Based Therapy for Adolescents (MBT-A) and Unified Protocol for Adolescents (UP-A). It involved 91 Iranian adolescents, mostly female, to see which treatment better reduces BPD symptoms. Methodology Participants were randomly…
Post-Acute Care Interventions for COPD Patients Study Overview This study focused on improving care for patients hospitalized due to COPD exacerbations in Switzerland. While inpatient care is good, there was a need for better post-acute care. An integrated care program was started at University Hospital Zurich to address this issue. Research Goals The goal was…
Overview of the CINTS-R Trial Background Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC). New methods like total neoadjuvant therapy (TNT) and immunotherapy are promising. We need better ways to select patients for these treatments. Our previous research shows that circulating tumour DNA (ctDNA) can help predict treatment outcomes and…
Topical Intranasal Anesthesia and Its Effects Background Topical intranasal anesthesia may affect how we perceive airflow in our noses. This could explain chronic nasal obstruction (CNO) in patients who do not have visible issues like deformities or inflammation. Our goal is to understand how this anesthesia impacts sensitivity in the nose and the feeling of…
A Study on Biosimilar Denosumab for Postmenopausal Osteoporosis Objective This study aimed to compare the safety and effectiveness of a biosimilar version of denosumab with the original product, Prolia, in Indian women with postmenopausal osteoporosis. Denosumab helps regulate bone turnover by decreasing bone loss. Methods This was a phase III, double-blind study involving postmenopausal women…
Comparative Efficacy of Lumbar and Pelvic Support for Postpartum Pain Study Overview This study examined how lumbar and pelvic supports help women with postpartum pelvic girdle pain (PPGP), a common issue after pregnancy. The goal was to see how these supports affect pain, disability, and movement control. Methodology 84 women diagnosed with pregnancy-related PPGP took…