Conditions: Primary Aldosteronism; Finerenone; Mineralocorticoid Receptor Antagonist
Interventions: Drug: Finerenone
Sponsors: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Recruiting
The Clinical Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism
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Clinical Research
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Results from a first-in-human phase i safety trial to evaluate the use of a vascularized pericranial/temporoparietal fascial flap to line the resection cavity following resection of newly diagnosed glioblastoma
“`html Summary of Clinical Trial Findings Purpose Glioblastoma (GBM) treatment limitations due to systemic toxicity and blood-brain barrier (BBB) permeability Use of vascularized flaps to bypass BBB and improve access…
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Safety and efficacy of genomic biomarker-guided neoadjuvant therapy for locally advanced and oligometastatic prostate cancer (SEGNO): study protocol for an open-label prospective phase II umbrella clinical trial
Background Managing locally advanced prostate cancer (PCa) and oligometastatic prostate cancer (OMPCa) is challenging. Because PCa can vary greatly from patient to patient, we need personalized treatment approaches. This study…
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Digital Therapeutic (Mika) Targeting Distress in Patients With Cancer: Results From a Nationwide Waitlist Randomized Controlled Trial
“`html Study Summary Distress is common among cancer patients, and many do not receive the support they need. The study aimed to test the effectiveness of Mika, a digital app,…
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Effect of Upper Body Flexibility Exercises on Respiratory Muscle Performance, Upper Limb Endurance and Activities of Daily Living in Patients With Chronic Respiratory Disease-A Randomized Control Trial
Background and Purpose Patients with chronic respiratory disease (CRD) often use their neck muscles for breathing, which can lead to poor posture and reduced muscle efficiency. Improving upper body flexibility…
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Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study
Tissue Doppler Echocardiography and Long-Term Cardiovascular Mortality Study Overview This study examines how tissue Doppler echocardiography can predict long-term cardiovascular mortality in hypertensive patients based on data from the Anglo-Scandinavian…
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A systematic review and meta-analysis of diagnostic performance of fluorescein-guided sentinel lymph node biopsy in early breast cancer
Diagnostic Performance of Fluorescein-Guided Sentinel Lymph Node Biopsy in Early Breast Cancer Practical Solutions and Value Traditional methods for evaluating axillary lymph nodes in early breast cancer are resource-intensive. Fluorescein…
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Frequency of red blood cell allo-immunization in patients undergoing blood transfusion at the Uganda Cancer Institute
Frequency of Red Blood Cell Allo-Immunization in Patients Undergoing Blood Transfusion at the Uganda Cancer Institute ABSTRACT There is limited data on red blood cell (RBC) alloimmunization in patients with…
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A randomized controlled clinical trial of concentrated growth factor combined with sodium hyaluronate in the treatment of temporomandibular joint osteoarthritis
Study Summary: Concentrated Growth Factor and Sodium Hyaluronate for Temporomandibular Joint Osteoarthritis Objective To assess the impact of concentrated growth factor (CGF) combined with sodium hyaluronate (SH) on temporomandibular joint…
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Online Disease Management Training for Older Adults With Osteoarthritis: A Randomized Controlled Trial
Online Disease Management Training for Older Adults With Osteoarthritis: A Randomized Controlled Trial Introduction Using online methods in health education is effective for providing individual services to older adults with…
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Chlorhexidine vs Routine Foot Washing to Prevent Diabetic Foot Ulcers: A Randomized Clinical Trial
Chlorhexidine vs Routine Foot Washing to Prevent Diabetic Foot Ulcers Study Overview This study aimed to find out if using chlorhexidine wipes daily is better than soap-and-water wipes for preventing…
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A Phase II Study of Neoadjuvant Chemoradiotherapy with Docetaxel, Cisplatin and 5-FU Followed by Surgical Resection in the Treatment of Locally Advanced Esophagogastric Junction Cancer and Locally Advanced Esophageal Cancer
“`html Phase II Study Summary A clinical trial was conducted to evaluate the effectiveness and safety of using a specific chemotherapy and radiotherapy regimen followed by surgery in treating advanced…
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Randomized study for a novel elbow joint fixation device on postoperative complications in patients undergoing percutaneous coronary diagnostic or therapeutic procedures through the brachial artery
Study Results: Novel Elbow Joint Fixation Device Reducing Complications in Brachial Artery Procedures Patients undergoing percutaneous coronary diagnostic or therapeutic procedures through the brachial artery face a higher risk of…
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Lung Cancer Screening Before and After a Multifaceted Electronic Health Record Intervention: A Nonrandomized Controlled Trial
Lung Cancer Screening Intervention Trial Key Findings Lung cancer is the deadliest cancer in the US, but early detection through screening improves outcomes. A nonrandomized controlled trial assessed a multifaceted…
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ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis
Understanding Insulin Resistance in Adolescents This study looks at how insulin resistance (IR) affects teenagers with obesity, especially focusing on fat tissue in their bodies. Key Findings Researchers tested 30…
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Molecular Landscape and Therapeutic Strategies against Colorectal Cancer
Molecular Landscape and Therapeutic Strategies against Colorectal Cancer Molecular Landscape and Therapeutic Strategies against Colorectal Cancer Practical Solutions and Value Colorectal cancer (CRC) is the second leading cause of cancer…
