Bayesian Population Pharmacokinetic Modeling of Ondansetron for Neonatal Opioid Withdrawal Syndrome
Summary
Ondansetron is a medication being tested for treating Neonatal Opioid Withdrawal Syndrome (NOWS) in newborns. This study analyzed data from a clinical trial involving 98 mother and newborn pairs. Pregnant women with opioid use disorder were given either a placebo or ondansetron right after delivery. Newborns whose mothers received ondansetron were treated with a small dose every day for up to five days.
Key Findings
- The study used advanced statistical methods to analyze the data.
- Results indicated that while the absorption rate was slower, factors like body weight were important for dosing, but the baby’s age did not significantly affect results.
- To effectively reduce withdrawal symptoms, at least three doses of oral ondansetron are recommended.
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