Analysing efficacy of low-dose oral minoxidil, topical minoxidil, and platelet-rich plasma with topical minoxidil combination in patients with androgenetic alopecia: a randomized controlled observer blinded trial

Study Overview

This study examines the effectiveness of three treatments for androgenetic alopecia (AGA): low-dose oral minoxidil, topical minoxidil, and a combination of platelet-rich plasma (PRP) with topical minoxidil.

Key Findings

  • 75 participants were divided into three groups of 25 each.
  • After 32 weeks, 25% of patients in the oral minoxidil and PRP groups improved by one grade in AGA severity, compared to 10% in the topical minoxidil group.
  • Hair density increased by 47.5% in the oral minoxidil group, 48% in the topical minoxidil group, and 57% in the PRP group, showing PRP as the most effective option.
  • Side effects were generally mild across all groups, with headaches and dizziness reported in the oral minoxidil group and scalp itching in the topical group.

Practical Solutions and Value

This study highlights low-dose oral minoxidil as a viable alternative to topical minoxidil for treating AGA. It also suggests that combining topical minoxidil with PRP may enhance treatment outcomes.

Importance of Clinical Trials

Clinical trials are essential for developing safe and effective treatments. They help integrate new findings into everyday medical practice.

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