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Itinai.com biomedical laboratory close up still scene close u fd75bc8f 7c64 495f bcb3 944db9509d75 2

Daratumumab in transplant-eligible patients with newly diagnosed multiple myeloma: final analysis of clinically relevant subgroups in GRIFFIN

Daratumumab in transplant-eligible patients with newly diagnosed multiple myeloma: final analysis of clinically relevant subgroups in GRIFFIN

Blood Cancer J. 2024 Jul 8;14(1):107. doi: 10.1038/s41408-024-01088-6.

The GRIFFIN study (NCT02874742) investigated daratumumab plus lenalidomide/bortezomib/dexamethasone (D-RVd) in newly diagnosed multiple myeloma (NDMM) patients who are eligible for transplant. The study’s final analysis focused on subgroups, including those with high-risk cytogenetic abnormalities (HRCAs). The results showed higher rates of minimal residual disease-negativity with D-RVd compared to RVd in various subgroups, indicating potential benefits of D-RVd in these patients.

Key Findings:

  • Higher minimal residual disease-negativity rates with D-RVd in patients ≥ 65 years, with HRCAs, and with gain/amp(1q21)
  • Trend toward improved progression-free survival with D-RVd in patients ≥ 65 years, with HRCAs, and with gain/amp(1q21)
  • Higher grade 3/4 treatment-emergent adverse event rates with D-RVd in patients ≥ 65 years

The results suggest that adding daratumumab to RVd may benefit transplant-eligible patients with high-risk NDMM. These findings provide valuable insights for clinical decision-making and potential treatment strategies.

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