Perturbational Complexity Index in Assessing rTMS Treatment for Disorders of Consciousness
Study Overview
A clinical trial investigated the use of repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Disorders of Consciousness (DoC). Patients in minimally conscious states participated in a randomized controlled trial to evaluate the effectiveness of rTMS in improving consciousness.
Key Findings
The study found that rTMS-active treatment led to significantly higher improvements in consciousness levels compared to rTMS-sham treatment. Results showed a positive response in 35% of patients. Those who responded to active rTMS had elevated scores in various measures, indicating a more favorable prognosis.
Practical Solutions and Value
Implementing 10 Hz rTMS in the left dorsolateral prefrontal cortex can effectively enhance consciousness in patients with DoC. The Perturbational Complexity Index (PCIst) emerged as a potential neurophysiological marker to assess and predict treatment efficacy.
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