The reduction of LEDD leads to visual dysfunction in patients with PD after STN-DBS: a randomized clinical trial

Background

After deep brain stimulation (DBS) for Parkinson’s disease (PD), changing medication doses may affect vision. However, no studies have specifically looked at this issue.

Objectives

This study aimed to compare the impact of reducing medication doses (levodopa-equivalent daily dose, or LEDD) on vision in PD patients after DBS.

Methods

In this clinical trial, 208 PD patients were enrolled from June 2019 to July 2021. They were divided into two groups: one group had their LEDD reduced, while the other did not. Vision was assessed 12 months after surgery using a questionnaire and other eye tests.

Results

In the short term, DBS did not significantly affect vision. However, in the long term, patients who had their LEDD reduced experienced worse vision and changes in eye structure compared to those who did not reduce their medication.

Conclusions

Reducing LEDD after DBS is linked to worsening vision. Continuing dopamine medications may help prevent these visual issues. Doctors should be mindful of adjusting medication doses if patients report vision problems before or after surgery.

Opportunities for Improvement

  • Define Measurable Outcomes: Establish clear goals to monitor vision changes related to LEDD adjustments.
  • Select AI Tools: Choose AI solutions that meet specific clinical needs for tracking patient outcomes.
  • Implement Step by Step: Start with a pilot project to track results, using AI to analyze the impact of LEDD changes on vision.

Contact Us for AI Solutions in Medical Management

For more information, reach out via:

AI Products for Business or Try Custom Development

AI Sales Bot

Welcome AI Sales Bot, your 24/7 teammate! Engaging customers in natural language across all channels and learning from your materials, it’s a step towards efficient, enriched customer interactions and sales

AI Document Assistant

Unlock insights and drive decisions with our AI Insights Suite. Indexing your documents and data, it provides smart, AI-driven decision support, enhancing your productivity and decision-making.

AI Customer Support

Upgrade your support with our AI Assistant, reducing response times and personalizing interactions by analyzing documents and past engagements. Boost your team and customer satisfaction

AI Scrum Bot

Enhance agile management with our AI Scrum Bot, it helps to organize retrospectives. It answers queries and boosts collaboration and efficiency in your scrum processes.