Smart Healthcare

Comparison between Reirradiation by Stereotactic Body Radiation Therapy and Moderately Hypofractionated Radiotherapy in Combination with Temozolomide for Treatment of Recurrent High Grade Glioma

Comparison between Reirradiation by Stereotactic Body Radiation Therapy and Moderately Hypofractionated Radiotherapy in Combination with Temozolomide for Treatment of Recurrent High Grade Glioma

Objective:

High grade glioma (HGG) often recurs and lacks a standard treatment. This study compared the effectiveness and side effects of two re-irradiation methods.

Methods:

Forty patients with recurrent HGG were divided into two groups. One received 30 Gy/10f/2w radiotherapy, and the other received stereotactic body radiotherapy (SBRT) 30 Gy/5f/1w, both with concurrent temozolomide (TMZ). Progression free survival (PFS) and overall survival (OS) were calculated, and brain MRI and toxicity were monitored.

Results:

The median PFS after recurrence was 6.4 months, median OS after recurrence was 8.6 months, and median total OS from diagnosis was 18.5 months. There was a significant improvement in PFS in the SBRT group, but no significant difference in OS. Patients tolerated the treatment well, with manageable acute and subacute side effects.

Conclusion:

Both re-irradiation methods were safe and effective, with SBRT showing a significant improvement in PFS.

AI Products for Business or Try Custom Development

AI Sales Bot

Welcome AI Sales Bot, your 24/7 teammate! Engaging customers in natural language across all channels and learning from your materials, it’s a step towards efficient, enriched customer interactions and sales

AI Document Assistant

Unlock insights and drive decisions with our AI Insights Suite. Indexing your documents and data, it provides smart, AI-driven decision support, enhancing your productivity and decision-making.

AI Customer Support

Upgrade your support with our AI Assistant, reducing response times and personalizing interactions by analyzing documents and past engagements. Boost your team and customer satisfaction

AI Scrum Bot

Enhance agile management with our AI Scrum Bot, it helps to organize retrospectives. It answers queries and boosts collaboration and efficiency in your scrum processes.