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Study of comparison of medical thoracoscopic guided biopsy versus closed pleural biopsy for etiological diagnosis of undiagnosed exudative pleural effusions: A randomized controlled study

Study Overview

This study compares two methods for diagnosing unknown causes of fluid in the lungs: medical thoracoscopy (MT) and closed pleural biopsy (CPB).

Background

Medical thoracoscopy is popular for diagnosing lung fluid issues, but it’s not commonly available in developing countries like India.

Aims

  • 1. To compare the effectiveness of CPB and MT in diagnosing undiagnosed exudative pleural effusions.
  • 2. To evaluate the complications of both procedures.

Methodology

This study involved 38 patients with unknown lung fluid diagnoses from January 2020 to September 2021. They were randomly divided into two groups:

  • Group A: 19 patients underwent Medical Thoracoscopy.
  • Group B: 19 patients underwent Closed Pleural Biopsy using a Cope’s needle.

Ultrasound was used to guide the procedure.

Results

  • Both MT and CPB had a diagnostic success rate of 78.9%.
  • CPB was significantly less painful than MT.
  • Patients undergoing CPB had a shorter hospital stay (P < 0.001).
  • CPB had a 5.3% mortality rate, while no deaths occurred in the MT group.

Conclusions

The study suggests that closed pleural biopsy is still a valuable tool for diagnosing lung fluid issues, especially in areas with high tuberculosis rates. It is also cost-effective for developing countries like India.

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