Short-term results of a multicenter study based on a modified N7 induction regimen combined with arsenic trioxide in the treatment of children with high-risk neuroblastoma

Short-term Study Results on Arsenic Trioxide Treatment for High-risk Neuroblastoma in Children

Overview

A clinical study was conducted to assess the effectiveness and safety of arsenic trioxide (ATO) in combination with a modified N7 induction regimen for children with high-risk neuroblastoma (NB).

Key Findings

  • 93% of patients achieved objective remission, with a 94% disease control rate.
  • Common adverse reactions included myelosuppression (90%), gastrointestinal symptoms (49%), infections (30%), hepatotoxicity (6%), and cardiovascular toxicity (2%).
  • No chemotherapy-related deaths were reported.

Practical Solutions and Value

The combination of ATO and N7-modified regimen showed superior efficacy and safety, highlighting its potential for wider clinical application.

Importance of Clinical Trials

Clinical trials play a vital role in developing safe and effective treatments. Extending their benefits to everyday medical practice is crucial for improving patient outcomes.

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